Fiche du document
2002
- doi: 10.1084/jem.20011658
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/doi/10.1084/jem.20011658
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/pmid/11854361
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/pissn/0022-1007
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_237878
info:eu-repo/semantics/openAccess , Copying allowed only for non-profit organizations , https://serval.unil.ch/disclaimer
Sujets proches
Thymus-dependent lymphocytes Thymus-derived cells T lymphocytes Thymus-dependent cells People Man Humanity (Human beings) Human race Mankind Homo sapiens Humankind Humans Older persons Older adults Seniors (Older people) Elderly people Old people Senior citizens Aging people AgedCiter ce document
A. Zippelius et al., « Thymic selection generates a large T cell pool recognizing a self-peptide in humans. », Serveur académique Lausannois, ID : 10.1084/jem.20011658
Métriques
Partage / Export
Résumé
The low frequency of self-peptide-specific T cells in the human preimmune repertoire has so far precluded their direct evaluation. Here, we report an unexpected high frequency of T cells specific for the self-antigen Melan-A/MART-1 in CD8 single-positive thymocytes from human histocompatibility leukocyte antigen-A2 healthy individuals, which is maintained in the peripheral blood of newborns and adults. Postthymic replicative history of Melan-A/MART-1-specific CD8 T cells was independently assessed by quantifying T cell receptor excision circles and telomere length ex vivo. We provide direct evidence that the large T cell pool specific for the self-antigen Melan-A/MART-1 is mostly generated by thymic output of a high number of precursors. This represents the only known naive self-peptide-specific T cell repertoire directly accessible in humans.