Shorter survival of SDF1-3'A/3'A homozygotes linked to CD4+ T cell decrease in advanced human immunodeficiency virus type 1 infection
Fiche du document
- doi: 10.1086/315650
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/doi/10.1086/315650
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/pmid/10882614
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/pissn/0022-1899
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_15251431BF3D2
info:eu-repo/semantics/openAccess , Copying allowed only for non-profit organizations , https://serval.unil.ch/disclaimer
Sujets proches
illnessCiter ce document
A. Brambilla et al., « Shorter survival of SDF1-3'A/3'A homozygotes linked to CD4+ T cell decrease in advanced human immunodeficiency virus type 1 infection », Serveur académique Lausannois, ID : 10.1086/315650
Métriques
Partage / Export
Résumé
The SDF-1 3'A allelic polymorphism has been reported to influence either positively or negatively the progression of human immunodeficiency virus type 1 (HIV-1) disease. Therefore, the SDF-1 genotype of 729 HIV-1-infected individuals pooled from 3 distinct cohorts was determined. A statistically nonsignificant association between the SDF1-3'A/3'A genotype and accelerated disease progression was evident among seroconverters (n=319), but a striking correlation of decreased survival after either diagnosis of AIDS according to the 1993 definition or loss of CD4(+) T cell counts