Virus burden in lymph nodes and blood of subjects with primary human immunodeficiency virus type 1 infection on bitherapy
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- doi: 10.1086/515303
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L. Perrin et al., « Virus burden in lymph nodes and blood of subjects with primary human immunodeficiency virus type 1 infection on bitherapy », Serveur académique Lausannois, ID : 10.1086/515303
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At present, it is not known whether undetectable plasma viremia corresponds to an absence of human immunodeficiency virus type 1 (HIV-1) replication in lymphoid tissues. This issue has been explored in 11 subjects with primary HIV-1 infection treated with zidovudine plus didanosine by evaluating virologic markers in blood and lymphoid tissues 9-18 months after initiation of treatment. These markers include plasma viremia, measured with a sensitive assay with a detection limit of 20 HIV-1 RNA copies/mL, infectious virus titers and proviral DNA in lymph node mononuclear cells, and HIV-1 RNA in lymphoid tissue. Five subjects had plasma viremia