Molecular epidemiology reveals long-term changes in HIV type 1 subtype B transmission in Switzerland.
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2010
- doi: 10.1086/651951
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Epidemiology--Molecular aspects Hours (Time) Animals--Phylogeny Phylogenetics Animal phylogeny Phylogeny (Zoology) Human males Disease outbreaks Outbreaks of disease Pestilences Diseases--OutbreaksCiter ce document
D. Kouyos Roger et al., « Molecular epidemiology reveals long-term changes in HIV type 1 subtype B transmission in Switzerland. », Serveur académique Lausannois, ID : 10.1086/651951
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BACKGROUND: Sequence data from resistance testing offer unique opportunities to characterize the structure of human immunodeficiency virus (HIV) infection epidemics. METHODS: We analyzed a representative set of HIV type 1 (HIV-1) subtype B pol sequences from 5700 patients enrolled in the Swiss HIV Cohort Study. We pooled these sequences with the same number of sequences from foreign epidemics, inferred a phylogeny, and identified Swiss transmission clusters as clades having a minimal size of 10 and containing >or=80% Swiss sequences. RESULTS: More than one-half of Swiss patients were included within 60 transmission clusters. Most transmission clusters were significantly dominated by specific transmission routes, which were used to identify the following patient groups: men having sex with men (MSM) (38 transmission clusters; average cluster size, 29 patients) or patients acquiring HIV through heterosexual contact (HETs) and injection drug users (IDUs) (12 transmission clusters; average cluster size, 144 patients). Interestingly, there were no transmission clusters dominated by sequences from HETs only. Although 44% of all HETs who were infected between 1983 and 1986 clustered with injection drug users, this percentage decreased to 18% for 2003-2006 (P