Molecular weight of hydroxyethyl starch: is there an effect on blood coagulation and pharmacokinetics?
Fiche du document
2005
- doi: 10.1093/bja/aei108
- issn: 0007-0912
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/doi/10.1093/bja/aei108
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/pmid/15734780
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/pissn/0007-0912
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_BBF95D7BBEE41
info:eu-repo/semantics/openAccess , Copying allowed only for non-profit organizations , https://serval.unil.ch/disclaimer
Sujets proches
Blood--Clotting Blood coagulation Clotting of blood Coagulation of blood Weight and measurementCiter ce document
C. Madjdpour et al., « Molecular weight of hydroxyethyl starch: is there an effect on blood coagulation and pharmacokinetics? », Serveur académique Lausannois, ID : 10.1093/bja/aei108
Métriques
Partage / Export
Résumé
BACKGROUND: The development of hydroxyethyl starches (HES) with low impact on blood coagulation but higher volume effect compared with the currently used HES solutions is of clinical interest. We hypothesized that high molecular weight, low-substituted HES might possess these properties. METHODS: Thirty pigs were infused with three different HES solutions (20 ml kg(-1)) with the same degree of molar substitution (0.42) but different molecular weights (130, 500 and 900 kDa). Serial blood samples were taken over 24 h and blood coagulation was assessed by Thromboelastograph analysis and analysis of plasma coagulation. In addition, plasma concentration and in vivo molecular weight were determined and pharmacokinetic data were computed based on a two-compartment model. RESULTS: Thromboelastograph analysis and plasma coagulation tests did not reveal a more pronounced alteration of blood coagulation with HES 500 and HES 900 compared with HES 130. In contrast, HES 500 and HES 900 had a greater area under the plasma concentration-time curve [1542 (142) g min litre(-1), P