Contribution of maternal antiretroviral therapy and breastfeeding to 24-month survival in human immunodeficiency virus-exposed uninfected children: An individual pooled analysis of African and Asian studies
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1 juin 2018
- doi: 10.1093/cid/cix1102
info:eu-repo/semantics/openAccess , http://creativecommons.org/licenses/by/
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ASIA AFRICA CHILD_SURVIVAL MATERNAL_BREASTFEEDING CHILDREN AIDS DRUGSSujets proches
Patients--Mortality Mortality, Law of Childhood Youngsters Pedology (Child study) Kids (Children) Western art (Western countries) Fine arts Iconography Arts, Fine Art, Occidental Arts, Visual Visual arts Occidental art Art, Visual Art, Western (Western countries) ArtsCiter ce document
Shino Arikawa et al., « Contribution of maternal antiretroviral therapy and breastfeeding to 24-month survival in human immunodeficiency virus-exposed uninfected children: An individual pooled analysis of African and Asian studies », Archined : l'archive ouverte de l'INED, ID : 10.1093/cid/cix1102
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Background Human immunodeficiency virus (HIV)–infected pregnant women increasingly receive antiretroviral therapy (ART) to prevent mother-to-child transmission (PMTCT). Studies suggest HIV-exposed uninfected (HEU) children face higher mortality than HIV-unexposed children, but most evidence relates to the pre-ART era, breastfeeding of limited duration, and considerable maternal mortality. Maternal ART and prolonged breastfeeding while on ART may improve survival, although this has not been reliably quantified. Methods Individual data on 19 219 HEU children from 21 PMTCT trials/cohorts undertaken from 1995 to 2015 in Africa and Asia were pooled to estimate the association between 24-month mortality and maternal/infant factors, using random-effects Cox proportional hazards models. Adjusted attributable fractions of risks computed using the predict function in the R package “frailtypack” were used to estimate the relative contribution of risk factors to overall mortality. Results Cumulative incidence of death was 5.5% (95% confidence interval, 5.1–5.9) by age 24 months. Low birth weight (LBW