How blood pressure predicts frailty transitions in older adults in a population-based cohort study: a multi-state transition model.
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10 août 2022
- doi: 10.1093/ije/dyab210
- issn: 0300-5771
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info:eu-repo/semantics/altIdentifier/pmid/34652417
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Older persons Older adults Seniors (Older people) Elderly people Old people Senior citizens Aging people AgedCiter ce document
D. Anker et al., « How blood pressure predicts frailty transitions in older adults in a population-based cohort study: a multi-state transition model. », Serveur académique Lausannois, ID : 10.1093/ije/dyab210
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Low blood pressure (BP) is associated with frailty in older adults. Our aim was to explore how BP predicts transitions between frailty states. We used data from the Lausanne cohort Lc65+, a population-based cohort of older adults randomly drawn from a population registry in Switzerland, in 2004, 2009 and 2014. BP was measured using a clinically validated oscillometric automated device and frailty was defined using Fried's phenotype, every 3 years. We used an illness-death discrete multi-state Markov model to estimate hazard ratios of forward and backward transitions between frailty states (outcome) in relation to BP categories (predictor of interest) with adjustment for sex, age and antihypertensive medication (other predictors). Among 4200 participants aged 65-70 years (58% female) at baseline, 70% were non-frail, 27% pre-frail and 2.0% frail. Over an average follow-up of 5.8 years, 2422 transitions were observed, with 1575 (65%) forward and 847 (35%) backward. Compared with systolic BP (SBP)