Renal perfusion evaluation with contrast-enhanced ultrasonography.

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Date

2012

Type de document
Périmètre
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Serveur académique Lausannois

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Ce document est lié à :
info:eu-repo/semantics/altIdentifier/doi/10.1093/ndt/gfr345

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/pmid/21690200

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/eissn/1460-2385

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_0FBD29996D506

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Serveur Académique Lausannois

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Université de Lausanne et CHUV

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info:eu-repo/semantics/openAccess , Copying allowed only for non-profit organizations , https://serval.unil.ch/disclaimer

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Adult; Angiotensin II/pharmacology; Captopril/pharmacology; Cohort Studies; Contrast Media/diagnostic use; Humans; Image Enhancement/methods; Kidney Cortex/blood supply; Kidney Cortex/drug effects; Male; Microcirculation/drug effects; Microcirculation/physiology; Observer Variation; Reference Values; Renal Circulation/drug effects; Renal Circulation/physiology; Renal Plasma Flow, Effective/drug effects; Sensitivity and Specificity; Ultrasonography, Doppler/methods; Young Adult

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Mercaptomethylpropanoylproline Mercaptomethylpropionylproline

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A.G. Schneider et al., « Renal perfusion evaluation with contrast-enhanced ultrasonography. », Serveur académique Lausannois, ID : 10.1093/ndt/gfr345

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BACKGROUND: Contrast-enhanced ultrasonography (CEUS) is a novel imaging technique that is safe and applicable on the bedside. Recent developments seem to enable CEUS to quantify organ perfusion. We performed an exploratory study to determine the ability of CEUS to detect changes in renal perfusion and to correlate them with effective renal plasma flow. METHODS: CEUS with destruction-refilling sequences was studied in 10 healthy subjects, at baseline and during infusion of angiotensin II (AngII) at low (1 ng/kg/min) and high dose (3 ng/kg/min) and 1 h after oral captopril (50 mg). Perfusion index (PI) was obtained and compared with the effective renal plasma flow (ERPF) obtained by parallel para-aminohippurate (PAH) clearance. RESULTS: Median PI decreased from 188.6 (baseline) to 100.4 with low-dose AngII (-47%; P < 0.02) and to 66.1 with high-dose AngII (-65%; P < 0.01) but increased to 254.7 with captopril (+35%; P > 0.2). These changes parallelled those observed with ERPF, which changed from a median of 672.1 mL/min (baseline) to 572.3 (low-dose AngII, -15%, P < 0.05) and to 427.2 (high-dose AngII, -36%, P < 0.001) and finally 697.1 (captopril, +4%, P < 0.02). CONCLUSIONS: This study demonstrates that CEUS is able to detect changes in human renal cortical microcirculation as induced by AngII infusion and/or captopril administration. The changes in perfusion indices parallel those in ERPF as obtained by PAH clearance.

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