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I Beuchat et al., « EEG findings in CART T associated neurotoxicity: clinical and radiological correlations. », Serveur académique Lausannois, ID : 10.1093/neuonc/noab174
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Background While EEG is frequently reported as abnormal after CAR T cell therapy, its clinical significance remains unclear. We aim to systematically describe EEG features in a large single center cohort and correlate them with clinical and radiological findings. Methods We retrospectively identified patients undergoing CAR T cell therapy who had continuous EEG. Neurotoxicity grades, detailed neurological symptoms and brain MRI or FDG-PET were obtained. Correlation between clinical and radiological findings and EEG features were assessed. Results In 81 patients with median neurotoxicity grade 3 (IQR 2-3), diffuse EEG background slowing was the most common finding and correlated with neurotoxicity severity (p