Obesity trends and body mass index changes after starting antiretroviral treatment : the Swiss HIV Cohort Study

B. Hasse; M. Iff; B. Ledergerber; A. Calmy; P. Schmid; C. Hauser; M. Cavassini; E. Bernasconi; C. Marzolini; P.E. Tarr; V. Aubert; J. Barth; M. Battegay; J. Böni; H.C. Bucher; M. Egger; L. Elzi; J. Fehr; J. Fellay; H. Furrer; C.A. Fux; M. Gorgievski; H. Günthard; D. Haerry; H.H. Hirsch; I. Hösli; C. Kahlert; L. Kaiser; O. Keiser; T. Klimkait; R. Kouyos; H. Kovari; G. Martinetti; B. Martinez de Tejada; K. Metzner; N. Müller; D. Nadal; G. Pantaleo; A. Rauch; S. Regenass; M. Rickenbach; C. Rudin; D. Schultze; J. Schüpbach; R. Speck; C. Staehelin; P. Tarr; A. Telenti; A. Trkola; P. Vernazza; R. Weber; S. Yerly

Obesity trends and body mass index changes after starting antiretroviral treatment : the Swiss HIV Cohort Study

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Date

2014

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Anglais

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doi: 10.1093/ofid/ofu040
issn: 2328-8957

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Serveur académique Lausannois

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Ce document est lié à :
info:eu-repo/semantics/altIdentifier/doi/10.1093/ofid/ofu040

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/pmid/25734114

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/eissn/2328-8957

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_44F79E67FED22

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Serveur Académique Lausannois

Organisation

Université de Lausanne et CHUV

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info:eu-repo/semantics/openAccess , CC BY-NC-ND 4.0 , https://creativecommons.org/licenses/by-nc-nd/4.0/

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B. Hasse et al., « Obesity trends and body mass index changes after starting antiretroviral treatment : the Swiss HIV Cohort Study », Serveur académique Lausannois, ID : 10.1093/ofid/ofu040

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BACKGROUND: The factors that contribute to increasing obesity rates in human immunodeficiency virus (HIV)-positive persons and to body mass index (BMI) increase that typically occurs after starting antiretroviral therapy (ART) are incompletely characterized. METHODS: We describe BMI trends in the entire Swiss HIV Cohort Study (SHCS) population and investigate the effects of demographics, HIV-related factors, and ART on BMI change in participants with data available before and 4 years after first starting ART. RESULTS: In the SHCS, overweight/obesity prevalence increased from 13% in 1990 (n = 1641) to 38% in 2012 (n = 8150). In the participants starting ART (n = 1601), mean BMI increase was 0.92 kg/m(2) per year (95% confidence interval, .83-1.0) during year 0-1 and 0.31 kg/m(2) per year (0.29-0.34) during years 1-4. In multivariable analyses, annualized BMI change during year 0-1 was associated with older age (0.15 [0.06-0.24] kg/m(2)) and CD4 nadir 350 (P < .001). Annualized BMI change during years 1-4 was associated with CD4 nadir 350 (P = .001) and black compared to white ethnicity (0.28 [0.16-0.37] kg/m(2)). Individual ART combinations differed little in their contribution to BMI change. CONCLUSIONS: Increasing obesity rates in the SHCS over time occurred at the same time as aging of the SHCS population, demographic changes, earlier ART start, and increasingly widespread ART coverage. Body mass index increase after ART start was typically biphasic, the BMI increase in year 0-1 being as large as the increase in years 1-4 combined. The effect of ART regimen on BMI change was limited.

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Obesity trends and body mass index changes after starting antiretroviral treatment : the Swiss HIV Cohort Study

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