Pulse wave amplitude drops during sleep: clinical significance and characteristics in a general population sample.
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13 juillet 2020
- doi: 10.1093/sleep/zsz322
- issn: 0161-8105
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info:eu-repo/semantics/altIdentifier/doi/10.1093/sleep/zsz322
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info:eu-repo/semantics/altIdentifier/pmid/31978212
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info:eu-repo/semantics/altIdentifier/eissn/1550-9109
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info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_17B727F30EDF3
info:eu-repo/semantics/openAccess , CC BY-NC-ND 4.0 , https://creativecommons.org/licenses/by-nc-nd/4.0/
Mots-clés
autonomic nervous system; biomarkers; cardiovascular medicine; diabetes; epidemiology; hypertensionSujets proches
Blood pressure, High Vascular hypertension High blood pressure Type 1 diabetes Brittle diabetes IDDM (Disease) Ketosis prone diabetes Diabetes mellitus Insulin-dependent diabetesCiter ce document
C. Hirotsu et al., « Pulse wave amplitude drops during sleep: clinical significance and characteristics in a general population sample. », Serveur académique Lausannois, ID : 10.1093/sleep/zsz322
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To explore the clinical significance of pulse wave amplitude (PWA)-drops during sleep as a biomarker for cardiometabolic disorders and describe their main characteristics in a general population sample. Cross-sectional study of HypnoLaus cohort, in which 2162 individuals underwent clinical assessment and in-home full polysomnography. PWA-drops were derived from photoplethysmography and processed using a validated automated algorithm. Associations between PWA-drop features (index, mean duration, and mean area under the curve [AUC]) with hypertension, diabetes, and previous cardiovascular (CV) event were analyzed using multivariable-adjusted logistic regression. Two thousand one hundred forty-nine participants (59 ± 11 years, 51% women, 9.9% diabetes, 41.3% hypertension, 4.4% CV event) were included. Mean ± standard deviation (SD) of PWA-drop index, duration, and AUC during sleep were 51.0 ± 20.3 events/hour, 14.0 ± 2.7 seconds, and 527±115 %seconds, respectively. PWA-drop index was lower in women and decreased with age, while its mean duration and AUC increased in men and elderly. Overall, lower PWA-drop index, longer duration and greater AUC were associated with increased odds of hypertension, diabetes, or CV event after adjustment for confounders. Participants in the lowest quartile of mean duration-normalized PWA-drop index had a significantly higher odds ratio (OR) of hypertension (OR = 1.60 [1.19-2.16]), CV event (OR = 3.26 [1.33-8.03]), and diabetes (OR = 1.71 [1.06-2.76]) compared to those in the highest quartile. Similar results were observed for mean AUC-normalized PWA-drop index regarding hypertension (OR = 1.59 [1.19-2.13]), CV event (OR = 2.45 [1.14-5.26]) and diabetes (OR = 1.76 [1.10-2.83]). PWA-drop features during sleep seem to be an interesting biomarker independently associated with cardiometabolic outcomes in the general population.