CD4/CD8 ratio and CD8 counts predict CD4 response in HIV-1-infected drug naive and in patients on cART.
Fiche du document
- doi: 10.1097/MD.0000000000005094
- issn: 0025-7974
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/doi/10.1097/MD.0000000000005094
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/pmid/27759638
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/eissn/1536-5964
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_F2B466D584315
info:eu-repo/semantics/openAccess , Copying allowed only for non-profit organizations , https://serval.unil.ch/disclaimer
Sujets proches
TherapyCiter ce document
R. Sauter et al., « CD4/CD8 ratio and CD8 counts predict CD4 response in HIV-1-infected drug naive and in patients on cART. », Serveur académique Lausannois, ID : 10.1097/MD.0000000000005094
Métriques
Partage / Export
Résumé
Plasma HIV viral load is related to declining CD4 lymphocytes. The extent to which CD8 cells, in addition to RNA viral load, predict the depletion of CD4 cells is not well characterized so far. We examine if CD8 cell count is a prognostic factor for CD4 cell counts during an HIV infection.A longitudinal analysis is conducted using data from the Swiss HIV cohort study collected between January 2000 and October 2014. Linear mixed regression models were applied to observations from HIV-1-infected treatment naive patients (NAIVE) and cART-treated patients to predict the short-term evolution of CD4 cell counts. For each subgroup, it was quantified to which extent CD8 cell counts or CD4/CD8 ratios are prognostic factors for disease progression.In both subgroups, 2500 NAIVE and 8902 cART patients, past CD4 cells are positively (P