Frequency and type of drug-related side effects necessitating treatment discontinuation in the Swiss Inflammatory Bowel Disease Cohort.

Fiche du document

Auteurs
Type de document
Périmètre
Langue
Identifiants
Source

Serveur académique Lausannois

Relations

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/doi/10.1097/MEG.0000000000001078

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/pmid/29384798

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/eissn/1473-5687

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_F310991788150

Collection

Serveur Académique Lausannois

Organisation

Université de Lausanne et CHUV

Licences

info:eu-repo/semantics/openAccess , Copying allowed only for non-profit organizations , https://serval.unil.ch/disclaimer

Mots-clés 0

Adolescent; Adult; Adverse Drug Reaction Reporting Systems; Aged; Aged, 80 and over; Anti-Inflammatory Agents/adverse effects; Chi-Square Distribution; Child; Child, Preschool; Colitis, Ulcerative/diagnosis; Colitis, Ulcerative/drug therapy; Colitis, Ulcerative/epidemiology; Crohn Disease/diagnosis; Crohn Disease/drug therapy; Crohn Disease/epidemiology; Drug Therapy, Combination; Drug-Related Side Effects and Adverse Reactions/diagnosis; Drug-Related Side Effects and Adverse Reactions/epidemiology; Female; Gastrointestinal Agents/adverse effects; Humans; Infant; Logistic Models; Male; Middle Aged; Multivariate Analysis; Odds Ratio; Retrospective Studies; Risk Factors; Switzerland/epidemiology; Young Adult

Sujets proches En

Therapy

Citer ce document

S. Godat et al., « Frequency and type of drug-related side effects necessitating treatment discontinuation in the Swiss Inflammatory Bowel Disease Cohort. », Serveur académique Lausannois, ID : 10.1097/MEG.0000000000001078

Métriques

Partage / Export

Résumé 0

Systematic analyses of inflammatory bowel disease (IBD) drug-related side effects necessitating treatment cessation in large cohorts of patients with IBD are scarce. We aimed to assess the frequency and type of drug-related side effects requiring drug cessation in patients included in the Swiss IBD Cohort. A retrospective review was performed of data from the Swiss IBD Cohort physician questionnaires documenting a treatment cessation for the following drug categories: aminosalicylates, topical and systemic steroids, thiopurines, methotrexate, tumor necrosis factor-antagonists, and calcineurin inhibitors (tacrolimus, cyclosporine). A total of 3192 patients were analyzed, of whom 1792 (56.1%) had Crohn's disease, 1322 (41.4%) had ulcerative colitis, and 78 (2.5%) had IBD unclassified. Of 3138 patients treated with IBD drugs, 2129 (67.8%) presented with one or several drug-related side effects necessitating drug cessation. We found a significant positive correlation between the number of concomitantly administered IBD drugs and the occurrence of side effects requiring drug cessation (P

document thumbnail

Par les mêmes auteurs

Sur les mêmes sujets