Height and timing of growth spurt during puberty in young people living with vertically acquired HIV in Europe and Thailand
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1 octobre 2019
info:eu-repo/semantics/openAccess , http://creativecommons.org/licenses/by/
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ADOLESCENTS CHILD_DEVELOPMENT BODY_HEIGHT THAILAND AIDS PUBERTY EUROPESujets proches
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Siobbhan Crichton et al., « Height and timing of growth spurt during puberty in young people living with vertically acquired HIV in Europe and Thailand », Archined : l'archive ouverte de l'INED, ID : 10.1097/QAD.0000000000002294
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Objective: To describe growth during puberty in young people with vertically acquired HIV. Design: Pooled data from 12 paediatric HIV cohorts in Europe and Thailand. Methods: 1094 children initiating an NNRTI- or boosted PI-based regimen aged 1 to 10 years were included. Super Imposition by Translation And Rotation (SITAR) models described growth from age 8 years using 3 parameters (average height, timing and shape of the growth spurt), dependent on age and height-for-age z-score (HAZ) (World Health Organisation references) at ART initiation. Multivariate regression explored characteristics associated with these 3 parameters. Results: At ART initiation median age and HAZ was 6.4[IQR:2.8,9.0] years and -1.2[-2.3,-0.2], respectively. Median follow-up was 9.1[6.9,11.4] years. In females, older age and lower HAZ at ART initiation were independently associated with a growth spurt which occurred 0.41 (95% CI 0.20,0.62) years later in children starting ART age 6-