IMPs: an RNA-binding protein family that provides a link between stem cell maintenance in normal development and cancer.
Fiche du document
15 novembre 2016
- doi: 10.1101/gad.287540.116
- issn: 0890-9369
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/doi/10.1101/gad.287540.116
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/pmid/27940961
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/eissn/1549-5477
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_C1371CD6ABBA5
info:eu-repo/semantics/openAccess , Copying allowed only for non-profit organizations , https://serval.unil.ch/disclaimer
Sujets proches
Upkeep Preventive maintenance Analysis (Mathematics) Carcinoma Cancers Malignancy (Cancer) Malignant tumorsCiter ce document
N. Degrauwe et al., « IMPs: an RNA-binding protein family that provides a link between stem cell maintenance in normal development and cancer. », Serveur académique Lausannois, ID : 10.1101/gad.287540.116
Métriques
Partage / Export
Résumé
IMPs, also known as insulin-like growth factor 2 (IGF2) messenger RNA (mRNA)-binding proteins (IGF2BPs), are highly conserved oncofetal RNA-binding proteins (RBPs) that regulate RNA processing at several levels, including localization, translation, and stability. Three mammalian IMP paralogs (IMP1-3) have been identified that are expressed in most organs during embryogenesis, where they are believed to play an important role in cell migration, metabolism, and stem cell renewal. Whereas some IMP2 expression is retained in several adult mouse organs, IMP1 and IMP3 are either absent or expressed at very low levels in most tissues after birth. However, all three paralogs can be re-expressed upon malignant transformation and are found in a broad range of cancer types where their expression often correlates with poor prognosis. IMPs appear to resume their physiological functions in malignant cells, which not only contribute to tumor progression but participate in the establishment and maintenance of tumor cell hierarchies. This review summarizes our current understanding of the functions of IMPs during normal development and focuses on a series of recent observations that have provided new insight into how their physiological functions enable IMPs to play a potentially key role in cancer stem cell maintenance and tumor growth.