Fiche du document
1 juillet 2020
- doi: 10.1101/gad.333989.119
- issn: 0890-9369
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/doi/10.1101/gad.333989.119
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/pmid/32611613
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/eissn/1549-5477
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_05D97F79A5F47
info:eu-repo/semantics/openAccess , CC BY 4.0 , https://creativecommons.org/licenses/by/4.0/
Mots-clés
Alu; BC200; RMRP; RNA polymerase III; cancer; disease; leukodystrophy; nc886; tRNA; transcriptionSujets proches
Speech--Transcription Language and languages--Transcription Transcribing Ribose nucleic acid Ribonucleic acid Analysis (Mathematics) TranscribingCiter ce document
M. Yeganeh et al., « RNA polymerase III transcription as a disease factor. », Serveur académique Lausannois, ID : 10.1101/gad.333989.119
Métriques
Partage / Export
Résumé
RNA polymerase (Pol) III is responsible for transcription of different noncoding genes in eukaryotic cells, whose RNA products have well-defined functions in translation and other biological processes for some, and functions that remain to be defined for others. For all of them, however, new functions are being described. For example, Pol III products have been reported to regulate certain proteins such as protein kinase R (PKR) by direct association, to constitute the source of very short RNAs with regulatory roles in gene expression, or to control microRNA levels by sequestration. Consistent with these many functions, deregulation of Pol III transcribed genes is associated with a large variety of human disorders. Here we review different human diseases that have been linked to defects in the Pol III transcription apparatus or to Pol III products imbalance and discuss the possible underlying mechanisms.