A bosentan pharmacokinetic study to investigate dosing regimens in paediatric patients with pulmonary arterial hypertension: FUTURE-3.

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Serveur académique Lausannois

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info:eu-repo/semantics/altIdentifier/doi/10.1111/bcp.13267

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info:eu-repo/semantics/altIdentifier/pmid/28213957

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info:eu-repo/semantics/altIdentifier/eissn/1365-2125

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info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_91482515D4DF9

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Serveur Académique Lausannois

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Université de Lausanne et CHUV

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info:eu-repo/semantics/openAccess , Copying allowed only for non-profit organizations , https://serval.unil.ch/disclaimer

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Administration, Oral; Antihypertensive Agents/pharmacokinetics; Antihypertensive Agents/therapeutic use; Area Under Curve; Child; Child, Preschool; Dose-Response Relationship, Drug; Drug Administration Schedule; Endothelin Receptor Antagonists/pharmacokinetics; Endothelin Receptor Antagonists/therapeutic use; Female; Humans; Hypertension, Pulmonary/drug therapy; Infant; Male; Prospective Studies; Sulfonamides/pharmacokinetics; Sulfonamides/therapeutic use; paediatrics; pharmacokinetics; vascular disease

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RMF Berger et al., « A bosentan pharmacokinetic study to investigate dosing regimens in paediatric patients with pulmonary arterial hypertension: FUTURE-3. », Serveur académique Lausannois, ID : 10.1111/bcp.13267

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The aim of the present study was to investigate whether increasing the bosentan dosing frequency from 2 mg kg -1 twice daily (b.i.d.) to 2 mg kg -1 three times daily (t.i.d.) in children with pulmonary arterial hypertension (PAH) (from ≥3 months to

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