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- doi: 10.1111/j.1600-0609.2009.01299.x
- issn: 0902-4441
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Leukaemia Leucocythemia Leucaemia Leucosis Leukosis Leucocythaemia LeucemiaCiter ce document
J. Neukirchen et al., « Platelet counts and haemorrhagic diathesis in patients with myelodysplastic syndromes. », Serveur académique Lausannois, ID : 10.1111/j.1600-0609.2009.01299.x
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Most patients with myelodysplastic syndromes (MDS) present with single or multiple lineage cytopenias in peripheral blood despite a hypercellular bone marrow. Thrombocytopenia, attributable to ineffective platelet production by dysfunctional megakaryocytes, has been estimated to occur in 40-65% of patients. However, there are hardly any studies on the clinical relevance of low platelet counts in MDS. We retrospectively analysed data from 2900 patients in the Duesseldorf MDS Registry who were diagnosed at our laboratory between 1982 and 2007. At the time of diagnosis, 43% of the patients had a platelet count lower than 100 000/microL. Platelets were lower than 20 000/microL in 7% of the patients, especially in those with advanced stages of MDS, who showed a higher frequency of thrombocytopenia and platelet transfusion dependency. On multivariate analysis, platelet anisometry, hypocellularity of megakaryopoiesis, maturational defects of megakaryocytes and platelets