Visceral leishmaniasis in a lung transplant recipient: usefulness of highly sensitive real-time polymerase chain reaction for preemptive diagnosis.

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Serveur académique Lausannois

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Ce document est lié à :
info:eu-repo/semantics/altIdentifier/doi/10.1111/tid.12585

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/pmid/27495987

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info:eu-repo/semantics/altIdentifier/eissn/1399-3062

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_930664C962556

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Serveur Académique Lausannois

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Université de Lausanne et CHUV

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info:eu-repo/semantics/openAccess , All rights reserved , https://serval.unil.ch/disclaimer

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Amphotericin B/administration & dosage; Amphotericin B/therapeutic use; Antiprotozoal Agents/administration & dosage; Antiprotozoal Agents/therapeutic use; DNA, Protozoan/isolation & purification; Early Diagnosis; Humans; Idiopathic Pulmonary Fibrosis/surgery; Leishmania/isolation & purification; Leishmaniasis, Visceral/blood; Leishmaniasis, Visceral/diagnosis; Leishmaniasis, Visceral/drug therapy; Leishmaniasis, Visceral/parasitology; Lung Transplantation/adverse effects; Male; Middle Aged; Parasite Load; Real-Time Polymerase Chain Reaction; Sensitivity and Specificity; Transplant Recipients; kinetoplastic DNA; leishmaniasis; lung transplant; preemptive diagnosis; real-time polymerase chain reaction; solid organ transplant

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Medical examinations (Diagnosis) Diseases--Diagnosis Diseases--Testing Examinations, Medical (Diagnosis) Medical diagnosis Medical tests (Diagnosis)

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O. Opota et al., « Visceral leishmaniasis in a lung transplant recipient: usefulness of highly sensitive real-time polymerase chain reaction for preemptive diagnosis. », Serveur académique Lausannois, ID : 10.1111/tid.12585

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We report the case of a lung transplant recipient in whom the diagnosis of visceral leishmaniasis (VL) was made by detection of parasites in a peripheral blood smear when the parasite load already reached 8.9 × 10(3) parasites/mL. We demonstrated that the VL diagnosis could have been done months before the development of symptoms by the use of Leishmania-specific real-time polymerase chain reaction (PCR), suggesting the role of preemptive PCR-based diagnosis in transplant recipients at risk for VL.

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