HIV Infection Functionally Impairs Mycobacterium tuberculosis-Specific CD4 and CD8 T-Cell Responses.
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1 mars 2019
- doi: 10.1128/JVI.01728-18
- issn: 0022-538X
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info:eu-repo/semantics/altIdentifier/doi/10.1128/JVI.01728-18
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info:eu-repo/semantics/altIdentifier/pmid/30541853
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info:eu-repo/semantics/altIdentifier/eissn/1098-5514
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info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_0A2A8987D5452
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P. Amelio et al., « HIV Infection Functionally Impairs Mycobacterium tuberculosis-Specific CD4 and CD8 T-Cell Responses. », Serveur académique Lausannois, ID : 10.1128/JVI.01728-18
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Résumé
Human immunodeficiency virus (HIV) infection is the major risk factor predisposing for Mycobacterium tuberculosis progression from latent tuberculosis infection (LTBI) to tuberculosis disease (TB). Since long-term-treated aviremic HIV-infected individuals remained at higher risk of developing TB than HIV-uninfected individuals, we hypothesized that progression from LTBI to pulmonary TB (PTB) might be due not only to CD4 T-cell depletion but also to M. tuberculosis-specific CD4 T-cell functional impairment. To test this hypothesis, M. tuberculosis-specific T-cell frequencies and cytokine profiles were investigated in untreated Tanzanian individuals suffering from LTBI (n = 20) or PTB (n = 67) and compared to those of untreated M. tuberculosis/HIV-coinfected individuals suffering from LTBI (n = 15) or PTB (n = 10). We showed that HIV infection significantly reduced the proportion of Th2 (interleukin 4 [IL-4]/IL-5/IL-13) producing M. tuberculosis-specific CD4 T cells and IL-2-producing M. tuberculosis-specific CD4 and CD8 T cells in individuals with LTBI or PTB (P