Is postoperative decrease of serum albumin an early predictor of complications after major abdominal surgery? A prospective cohort study in a European centre.

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Date

8 avril 2017

Type de document
Périmètre
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Source

Serveur académique Lausannois

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Ce document est lié à :
info:eu-repo/semantics/altIdentifier/doi/10.1136/bmjopen-2016-013966

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/pmid/28391235

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/eissn/2044-6055

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_03EEEB1F34619

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Serveur Académique Lausannois

Organisation

Université de Lausanne et CHUV

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info:eu-repo/semantics/openAccess , CC BY-NC-ND 4.0 , https://creativecommons.org/licenses/by-nc-nd/4.0/

Mots-clés 0

Abdomen/surgery; Adult; Aged; Biomarkers; C-Reactive Protein/metabolism; Calcitonin/metabolism; Elective Surgical Procedures/adverse effects; Female; Humans; Male; Middle Aged; Postoperative Complications/metabolism; Postoperative Period; Predictive Value of Tests; Prospective Studies; Protein Precursors; Serum Albumin/metabolism; Switzerland/epidemiology; Biomarker; albumin; major surgery; postoperative complications; stress response

Sujets proches En

Diseases--Surgery Surgery, Primitive Seralbumin Plasma albumin

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I. Labgaa et al., « Is postoperative decrease of serum albumin an early predictor of complications after major abdominal surgery? A prospective cohort study in a European centre. », Serveur académique Lausannois, ID : 10.1136/bmjopen-2016-013966

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To test postoperative serum albumin drop (ΔAlb) as a marker of surgical stress response and early predictor of clinical outcomes. Prospective cohort study (NCT02356484). Albumin was prospectively measured in 138 patients undergoing major abdominal surgery. Blood samples were collected before surgery and on postoperative days 0, 1 2 and 3. ΔAlb was compared to the modified estimation of physiologic ability and surgical stress (mE-PASS) score and correlated to the performances of C reactive protein (CRP), procalcitonin (PCT) and lactate (LCT). Postoperative outcomes were postoperative complications according to Clavien classification and Comprehensive Complication Index (CCI), and length of hospital stay (LoS). Department of abdominal surgery in a European tertiary centre. Adult patients undergoing elective major abdominal surgery, with anticipated duration ≥2 hours. Patients on immunosuppressive or antibiotic treatments before surgery were excluded. The level of serum albumin rapidly dropped after surgery. ΔAlb correlated to the mE-PASS score (r=0.275, p=0.01) and to CRP increase (r=0.536, p

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