Consensus guidelines for the definition, detection and interpretation of immunogenic cell death.

L. Galluzzi; I. Vitale; S. Warren; S. Adjemian; P. Agostinis; A.B. Martinez; T.A. Chan; G. Coukos; S. Demaria; E. Deutsch; D. Draganov; R.L. Edelson; S.C. Formenti; J. Fucikova; L. Gabriele; U.S. Gaipl; S.R. Gameiro; A.D. Garg; E. Golden; J. Han; K.J. Harrington; A. Hemminki; J.W. Hodge; DMS Hossain; T. Illidge; M. Karin; H.L. Kaufman; O. Kepp; G. Kroemer; J.J. Lasarte; S. Loi; M.T. Lotze; G. Manic; T. Merghoub; A.A. Melcher; K.L. Mossman; F. Prosper; Ø. Rekdal; M. Rescigno; C. Riganti; A. Sistigu; M.J. Smyth; R. Spisek; J. Stagg; B.E. Strauss; D. Tang; K. Tatsuno; S.W. van Gool; P. Vandenabeele; T. Yamazaki; D. Zamarin; L. Zitvogel; A. Cesano; F.M. Marincola

Consensus guidelines for the definition, detection and interpretation of immunogenic cell death.

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Histoire, Philosophie et Sociologie des sciences

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Anglais

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doi: 10.1136/jitc-2019-000337
issn: 2051-1426

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Serveur académique Lausannois

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Ce document est lié à :
info:eu-repo/semantics/altIdentifier/doi/10.1136/jitc-2019-000337

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/pmid/32209603

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/eissn/2051-1426

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_56620B5927E22

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Serveur Académique Lausannois

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Université de Lausanne et CHUV

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info:eu-repo/semantics/openAccess , CC BY 4.0 , https://creativecommons.org/licenses/by/4.0/

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Consensus; Guidelines as Topic; Humans; Immunogenic Cell Death/genetics; Molecular Biology/methods; immunology; molecular biology; oncology

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Cell degeneration

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L. Galluzzi et al., « Consensus guidelines for the definition, detection and interpretation of immunogenic cell death. », Serveur académique Lausannois, ID : 10.1136/jitc-2019-000337

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Cells succumbing to stress via regulated cell death (RCD) can initiate an adaptive immune response associated with immunological memory, provided they display sufficient antigenicity and adjuvanticity. Moreover, multiple intracellular and microenvironmental features determine the propensity of RCD to drive adaptive immunity. Here, we provide an updated operational definition of immunogenic cell death (ICD), discuss the key factors that dictate the ability of dying cells to drive an adaptive immune response, summarize experimental assays that are currently available for the assessment of ICD in vitro and in vivo, and formulate guidelines for their interpretation.

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Consensus guidelines for the definition, detection and interpretation of immunogenic cell death.

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