Low-dose irradiation for reversing immunotherapy resistance: how to translate?

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Serveur académique Lausannois

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Ce document est lié à :
info:eu-repo/semantics/altIdentifier/doi/10.1136/jitc-2022-004939

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/pmid/35835490

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info:eu-repo/semantics/altIdentifier/eissn/2051-1426

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_DBBB9D3370A59

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Serveur Académique Lausannois

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Université de Lausanne et CHUV

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info:eu-repo/semantics/openAccess , CC BY-NC 4.0 , https://creativecommons.org/licenses/by-nc/4.0/

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Adaptive Immunity; Humans; Immunologic Factors; Immunotherapy; Neoplasms/drug therapy; Neoplasms/radiotherapy; Tumor Microenvironment; Drug Therapy, Combination; Immunity, Innate; Radiotherapy

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Therapeutic immunology

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M. Ochoa-de-Olza et al., « Low-dose irradiation for reversing immunotherapy resistance: how to translate? », Serveur académique Lausannois, ID : 10.1136/jitc-2022-004939

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The use of low-dose irradiation (LDI) for mobilizing innate and adaptive immunity is gaining interest among the scientific community. Recent evidence suggests that LDI can reprogramme the tumor microenvironment, induce inflammation and turn cold tumors susceptible to immunecheckpoint blockade therapy. Translating immuno-radiation preclinical findings in the clinic is more challenging than expected. We propose therapeutic strategies for combining LDI with immunotherapy, and emphasize the importance of pursuing clinical research to determine optimal radiation dosage, fractionation, volumes, and sequencing to stimulate immune-mediated tumor responses.

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