Early profiles of clinical evolution after intravenous thrombolysis in an unselected stroke population.

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M.G. Delgado et al., « Early profiles of clinical evolution after intravenous thrombolysis in an unselected stroke population. », Serveur académique Lausannois, ID : 10.1136/jnnp.2009.185363


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Abstract 0

Intravenous recombinant tissular plasminogen activator (rt-PA) is the only approved pharmacological treatment for acute ischaemic stroke. The authors aimed to analyse potential causes of the variable effect on early course and late outcome. 136 patients (42% women, 58% men) treated with intravenous rt-PA within 3 h of stroke onset in an acute stroke unit over a 3-year period, were included. Early clinical profiles of evolution at 48 h were divided into clinical improvement (CI) (decrease >4 points in the National Institute of Health Stroke Scale (NIHSS)); clinical worsening (CW) (increase >4 points NIHSS); clinical worsening after initial improvement (CWFI) (variations of >4 points in the NIHSS). Patients with clinical stability (no NIHSS modification or

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