Recovery after unilateral knee replacement due to severe osteoarthritis and progression in the contralateral knee: a randomised clinical trial comparing daily 2000 IU versus 800 IU vitamin D.
Fiche du document
2018
- doi: 10.1136/rmdopen-2018-000678
- issn: 2056-5933
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/doi/10.1136/rmdopen-2018-000678
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/pmid/30018805
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/pissn/2056-5933
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_BA746718876E4
info:eu-repo/semantics/openAccess , CC BY-NC 4.0 , https://creativecommons.org/licenses/by-nc/4.0/
Sujets proches
Genus (Anatomy) Knee joint GenuCiter ce document
H.A. Bischoff-Ferrari et al., « Recovery after unilateral knee replacement due to severe osteoarthritis and progression in the contralateral knee: a randomised clinical trial comparing daily 2000 IU versus 800 IU vitamin D. », Serveur académique Lausannois, ID : 10.1136/rmdopen-2018-000678
Métriques
Partage / Export
Résumé
To test whether daily high-dose vitamin D improves recovery after unilateral total knee replacement. Data come from a 24-month randomised, double-blind clinical trial. Adults aged 60 and older undergoing unilateral joint replacement due to severe knee osteoarthritis were 6-8 weeks after surgery randomly assigned to receive daily high-dose (2000 IU) or standard-dose (800 IU) vitamin D 3 . The primary endpoints were symptoms (Western Ontario and McMaster Universities Arthritis Index pain and function scores) assessed at baseline, 6, 12, 18 and 24 months in both knees, and the rate of falls over 24 months. The secondary outcomes were sit-to-stand performance, gait speed, physical activity and radiographic progression in the contralateral knee. We recruited 273 participants, 137 were randomised to receive 2000 IU and 136 were randomised to receive 800 IU vitamin D per day. 2000 IU vitamin D increased 25-hydroxyvitamin D levels to 45.6 ng/mL and 800 IU vitamin D to 37.1 ng/mL at month 24 (p