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2014
- doi: 10.1152/physiol.00021.2013
- issn: 1548-9221
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Diseases and hygiene Balance Service of process Service of papers Abuse of process Process Blood pressure, High Vascular hypertension High blood pressure Analysis (Mathematics) Proof Balancing (Physics) Balance (Physics) Balance Sickness Human beings--Diseases Morbidity Illness Sicknesses Illnesses Blood--PressureCiter ce document
C. Ronzaud et al., « Ubiquitylation and control of renal na+ balance and blood pressure. », Serveur académique Lausannois, ID : 10.1152/physiol.00021.2013
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Ubiquitylation is crucial for regulating numerous cellular functions. In the kidney, ubiquitylation regulates the epithelial Na(+) channel ENaC. The importance of this process is highlighted in Liddle's syndrome, where mutations interfere with ENaC ubiquitylation, resulting in constitutive Na(+) reabsorption and hypertension. There is emerging evidence that NCC, involved in hypertensive diseases, is also regulated by ubiquitylation. Here, we discuss the current knowledge and recent findings in this field.