Sézary Syndrome and Atopic Dermatitis: Comparison of Immunological Aspects and Targets.

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Auteurs
Date

2016

Type de document
Périmètre
Langue
Identifiant
Source

Serveur académique Lausannois

Relations

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/doi/10.1155/2016/9717530

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/pmid/27294147

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/eissn/2314-6141

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_966C0C4FCBD97

Collection

Serveur Académique Lausannois

Organisation

Université de Lausanne et CHUV

Licences

info:eu-repo/semantics/openAccess , CC BY 4.0 , https://creativecommons.org/licenses/by/4.0/

Mots-clés 0

Cytokines/blood; Dermatitis, Atopic/blood; Dermatitis, Atopic/immunology; Dermatitis, Atopic/pathology; Dermatitis, Atopic/therapy; Humans; Immunoglobulin E/blood; Lymphoma, T-Cell, Cutaneous/blood; Lymphoma, T-Cell, Cutaneous/immunology; Lymphoma, T-Cell, Cutaneous/pathology; Lymphoma, T-Cell, Cutaneous/therapy; Sezary Syndrome/blood; Sezary Syndrome/immunology; Sezary Syndrome/pathology; Sezary Syndrome/therapy; Th2 Cells/immunology; Th2 Cells/pathology

Sujets proches En

Lymphoma Non-Hodgkin's lymphoma Germinoblastomas Sarcoma, Germinoblastic Sarcoma, Immunoblastic Reticulolymphosarcomas Immunoblastomas

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I. Saulite et al., « Sézary Syndrome and Atopic Dermatitis: Comparison of Immunological Aspects and Targets. », Serveur académique Lausannois, ID : 10.1155/2016/9717530

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Sézary syndrome (SS), an aggressive form of erythrodermic pruritic cutaneous T cell lymphoma (CTCL), from an immunological perspective characterized by increased Th2 cytokine levels, elevated serum IgE and impaired cellular immunity. Not only the clinical appearance but also the hallmark immunological characteristics of SS often share striking similarities with acute flares of atopic dermatitis (AD), a common benign chronic inflammatory skin disease. Given the overlap of several immunological features, the application of similar or even identical therapeutic approaches in certain stages of both diseases may come into consideration. The aim of this review is to compare currently accepted immunological aspects and possible therapeutic targets in AD and SS.

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