Regional coronary endothelial function is closely related to local early coronary atherosclerosis in patients with mild coronary artery disease: pilot study.

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Date

2012

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Serveur académique Lausannois

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Ce document est lié à :
info:eu-repo/semantics/altIdentifier/doi/10.1161/CIRCIMAGING.111.969691

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/pmid/22492483

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/eissn/1942-0080

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_8102A2214B2A8

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Serveur Académique Lausannois

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Université de Lausanne et CHUV

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info:eu-repo/semantics/openAccess , Copying allowed only for non-profit organizations , https://serval.unil.ch/disclaimer

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Adolescent; Adult; Aged; Coronary Angiography/methods; Coronary Artery Disease/complications; Coronary Artery Disease/etiology; Coronary Stenosis/etiology; Coronary Stenosis/physiopathology; Endothelium, Vascular/physiopathology; Endothelium, Vascular/radiography; Female; Humans; Image Processing, Computer-Assisted/methods; Magnetic Resonance Imaging/methods; Male; Middle Aged; Pilot Projects; Severity of Illness Index; Young Adult

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illness

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A.G. Hays et al., « Regional coronary endothelial function is closely related to local early coronary atherosclerosis in patients with mild coronary artery disease: pilot study. », Serveur académique Lausannois, ID : 10.1161/CIRCIMAGING.111.969691

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BACKGROUND: Coronary endothelial function is abnormal in patients with established coronary artery disease and was recently shown by MRI to relate to the severity of luminal stenosis. Recent advances in MRI now allow the noninvasive assessment of both anatomic and functional (endothelial function) changes that previously required invasive studies. We tested the hypothesis that abnormal coronary endothelial function is related to measures of early atherosclerosis such as increased coronary wall thickness. METHODS AND RESULTS: Seventeen arteries in 14 healthy adults and 17 arteries in 14 patients with nonobstructive coronary artery disease were studied. To measure endothelial function, coronary MRI was performed before and during isometric handgrip exercise, an endothelial-dependent stressor, and changes in coronary cross-sectional area and flow were measured. Black blood imaging was performed to quantify coronary wall thickness and indices of arterial remodeling. The mean stress-induced change in cross-sectional area was significantly higher in healthy adults (13.5%±12.8%, mean±SD, n=17) than in those with mildly diseased arteries (-2.2%±6.8%, P

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