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2006
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info:eu-repo/semantics/altIdentifier/doi/10.1186/1471-2369-7-3
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info:eu-repo/semantics/altIdentifier/pmid/16515712
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info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_89AE09013B1C4
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J.C. Luthi et al., « Anemia and chronic kidney disease are associated with poor outcomes in heart failure patients. », Serveur académique Lausannois, ID : 10.1186/1471-2369-7-3
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BACKGROUND: Chronic kidney disease (CKD) has been linked to higher heart failure (HF) risk. Anemia is a common consequence of CKD, and recent evidence suggests that anemia is a risk factor for HF. The purpose of this study was to examine among patients with HF, the association between CKD, anemia and inhospital mortality and early readmission. METHODS: We performed a retrospective cohort study in two Swiss university hospitals. Subjects were selected based the presence of ICD-10 HF codes in 1999. We recorded demographic characteristics and risk factors for HF. CKD was defined as a serum creatinine > or = 124 956;mol/L for women and > or = 133 micromol/L for men. The main outcome measures were inhospital mortality and thirty-day readmissions. RESULTS: Among 955 eligible patients hospitalized with heart failure, 23.0% had CKD. Twenty percent and 6.1% of individuals with and without CKD, respectively, died at the hospital (p < 0.0001). Overall, after adjustment for other patient factors, creatinine and hemoglobin were associated with an increased risk of death at the hospital, and hemoglobin was related to early readmission. CONCLUSION: Both CKD and anemia are frequent among older patients with heart failure and are predictors of adverse outcomes, independent of other known risk factors for heart failure.