Indacaterol and glycopyrronium versus indacaterol on body plethysmography measurements in COPD-a randomised controlled study.

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Date

11 janvier 2017

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Serveur académique Lausannois

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info:eu-repo/semantics/altIdentifier/doi/10.1186/s12931-016-0498-1

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/pmid/28077140

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info:eu-repo/semantics/altIdentifier/eissn/1465-993X

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_A7E2FF85535D3

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Serveur Académique Lausannois

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Université de Lausanne et CHUV

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info:eu-repo/semantics/openAccess , Copying allowed only for non-profit organizations , https://serval.unil.ch/disclaimer

Mots-clés 0

Adrenergic beta-2 Receptor Agonists/administration & dosage; Adult; Aged; Aged, 80 and over; Cross-Over Studies; Diagnosis, Computer-Assisted/methods; Double-Blind Method; Drug Combinations; Female; Glycopyrrolate/administration & dosage; Humans; Indans/administration & dosage; Male; Middle Aged; Muscarinic Antagonists/administration & dosage; Placebo Effect; Plethysmography, Whole Body/methods; Pulmonary Disease, Chronic Obstructive/diagnosis; Pulmonary Disease, Chronic Obstructive/drug therapy; Pulmonary Disease, Chronic Obstructive/physiopathology; Quinolones/administration & dosage; Reproducibility of Results; Respiratory Function Tests/methods; Sensitivity and Specificity; Spirometry/methods; Switzerland; Treatment Outcome; Body plethysmography; COPD; Glycopyrronium; Indacaterol; Spirometry

Sujets proches En

Therapy Lung Older persons Older adults Seniors (Older people) Elderly people Old people Senior citizens Aging people Aged

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J. Salomon et al., « Indacaterol and glycopyrronium versus indacaterol on body plethysmography measurements in COPD-a randomised controlled study. », Serveur académique Lausannois, ID : 10.1186/s12931-016-0498-1

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Dual bronchodilator therapy is recommended for symptomatic patients with chronic obstructive pulmonary disease (COPD). There are limited data on effects of a combination of two long-acting bronchodilators on lung function including body plethysmography. This multicentre, randomised, double-blind, single-dose, cross-over, placebo-controlled study evaluated efficacy and safety of the free combination of indacaterol maleate (IND) and glycopyrronium bromide (GLY) versus IND alone on spirometric and body plethysmography parameters, including inspiratory capacity (IC), forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC), total lung capacity (TLC) and airway resistance (Raw) in moderate-to-severe COPD patients. Seventy-eight patients with FEV1 % pred. (mean ± SD) 56 ± 13% were randomised. The combination of IND + GLY versus IND presented a numerically higher peak-IC (Δ = 0.076 L, 95% confidence interval [CI]: -0.010 - 0.161 L; p = 0.083), with a statistically significant difference in mean IC over 4 h (Δ = 0.054 L, 95%CI 0.022 - 0.086 L; p = 0.001). FEV1, FVC and Raw, but not TLC, were consistently significantly improved by IND + GLY compared to IND alone. Safety profiles of both treatments were comparable. The free combination of IND + GLY improved lung function parameters as evaluated by spirometry and body plethysmography, with a similar safety profile compared to IND alone. NCT01699685.

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