Local coronary wall eccentricity and endothelial function are closely related in patients with atherosclerotic coronary artery disease.
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6 juillet 2017
- doi: 10.1186/s12968-017-0358-2
- issn: 1097-6647
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A.G. Hays et al., « Local coronary wall eccentricity and endothelial function are closely related in patients with atherosclerotic coronary artery disease. », Serveur académique Lausannois, ID : 10.1186/s12968-017-0358-2
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Coronary endothelial function (CEF) in patients with coronary artery disease (CAD) varies among coronary segments in a given patient. Because both coronary vessel wall eccentricity and coronary endothelial dysfunction are predictors of adverse outcomes, we hypothesized that local coronary endothelial dysfunction is associated with local coronary artery eccentricity. We used 3 T coronary CMR to measure CEF as changes in coronary cross-sectional area (CSA) and coronary blood flow (CBF) during isometric handgrip exercise (IHE), a known endothelial-dependent stressor, in 29 patients with known CAD and 16 healthy subjects. Black-blood MRI quantified mean coronary wall thickness (CWT) and coronary eccentricity index (EI) and CEF was determined in the same segments. IHE-induced changes in CSA and CBF in healthy subjects (10.6 ± 6.6% and 38.3 ± 29%, respectively) were greater than in CAD patients 1.3 ± 7.7% and 6.5 ± 19.6%, respectively, p