Ce document est lié à :
info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pgen.1000791
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/pmid/20041166
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/eissn/1553-7404
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_86D58F4F43489
info:eu-repo/semantics/openAccess , Copying allowed only for non-profit organizations , https://serval.unil.ch/disclaimer
J. Fellay et al., « Common genetic variation and the control of HIV-1 in humans. », Serveur académique Lausannois, ID : 10.1371/journal.pgen.1000791
To extend the understanding of host genetic determinants of HIV-1 control, we performed a genome-wide association study in a cohort of 2,554 infected Caucasian subjects. The study was powered to detect common genetic variants explaining down to 1.3% of the variability in viral load at set point. We provide overwhelming confirmation of three associations previously reported in a genome-wide study and show further independent effects of both common and rare variants in the Major Histocompatibility Complex region (MHC). We also examined the polymorphisms reported in previous candidate gene studies and fail to support a role for any variant outside of the MHC or the chemokine receptor cluster on chromosome 3. In addition, we evaluated functional variants, copy-number polymorphisms, epistatic interactions, and biological pathways. This study thus represents a comprehensive assessment of common human genetic variation in HIV-1 control in Caucasians.