Association of eGFR-Related Loci Identified by GWAS with Incident CKD and ESRD.

C.A. Böger; M. Gorski; M. Li; M.M. Hoffmann; C. Huang; Q. Yang; A. Teumer; V. Krane; C.M. O'Seaghdha; Z. Kutalik; H.E. Wichmann; T. Haak; E. Boes; S. Coassin; J. Coresh; B. Kollerits; M. Haun; B. Paulweber; A. Köttgen; G. Li; M.G. Shlipak; N. Powe; S.J. Hwang; A. Dehghan; F. Rivadeneira; A. Uitterlinden; A. Hofman; J.S. Beckmann; B.K. Krämer; J. Witteman; M. Bochud; D. Siscovick; R. Rettig; F. Kronenberg; C. Wanner; R.I. Thadhani; I.M. Heid; C.S. Fox; W.H. Kao

Association of eGFR-Related Loci Identified by GWAS with Incident CKD and ESRD.

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Auteurs

Date

2011

Type de document

Articles

Périmètre

Publications

Langue

Anglais

Identifiants

doi: 10.1371/journal.pgen.1002292
issn: 1553-7390

Source

Serveur académique Lausannois

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Ce document est lié à :
info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pgen.1002292

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/pmid/21980298

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/eissn/1553-7404

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_CB7DEB8984199

Collection

Serveur Académique Lausannois

Organisation

Université de Lausanne et CHUV

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info:eu-repo/semantics/openAccess , Copying allowed only for non-profit organizations , https://serval.unil.ch/disclaimer

Mots-clés 0

Adaptor Proteins, Signal Transducing/genetics; Adult; Aged; Chronic Disease; Creatinine/blood; European Continental Ancestry Group/genetics; Female; Follow-Up Studies; Genetic Association Studies; Humans; Kidney Diseases/etiology; Kidney Diseases/genetics; Kidney Failure, Chronic/etiology; Kidney Failure, Chronic/genetics; Male; Middle Aged; Polymorphism, Single Nucleotide; Receptor, Epidermal Growth Factor/genetics; Uromodulin/genetics

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Group dynamics Association Groups, Social

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C.A. Böger et al., « Association of eGFR-Related Loci Identified by GWAS with Incident CKD and ESRD. », Serveur académique Lausannois, ID : 10.1371/journal.pgen.1002292

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Family studies suggest a genetic component to the etiology of chronic kidney disease (CKD) and end stage renal disease (ESRD). Previously, we identified 16 loci for eGFR in genome-wide association studies, but the associations of these single nucleotide polymorphisms (SNPs) for incident CKD or ESRD are unknown. We thus investigated the association of these loci with incident CKD in 26,308 individuals of European ancestry free of CKD at baseline drawn from eight population-based cohorts followed for a median of 7.2 years (including 2,122 incident CKD cases defined as eGFR

Association of eGFR-Related Loci Identified by GWAS with Incident CKD and ESRD.

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