Targeting vascular NADPH oxidase 1 blocks tumor angiogenesis through a PPARα mediated mechanism.

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2011

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Serveur académique Lausannois

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This document is linked to :
info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0014665

This document is linked to :
info:eu-repo/semantics/altIdentifier/pmid/21326871

This document is linked to :
info:eu-repo/semantics/altIdentifier/eissn/1932-6203

This document is linked to :
info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_E36D61042E0B8

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Serveur Académique Lausannois

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Université de Lausanne et CHUV

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info:eu-repo/semantics/openAccess , Copying allowed only for non-profit organizations , https://serval.unil.ch/disclaimer

Keywords 0

Angiogenesis Inhibitors/pharmacology; Angiogenesis Inhibitors/therapeutic use; Animals; Cells, Cultured; Endothelial Cells/drug effects; Endothelial Cells/metabolism; Female; Gene Knockdown Techniques; Gene Targeting; Humans; Mice; Mice, Inbred C57BL; Mice, Knockout; Models, Biological; Molecular Targeted Therapy; NADH, NADPH Oxidoreductases/antagonists & inhibitors; NADH, NADPH Oxidoreductases/genetics; Neoplasms/blood supply; Neoplasms/drug therapy; Neovascularization, Pathologic/drug therapy; Neovascularization, Pathologic/genetics; PPAR alpha/genetics; PPAR alpha/physiology; Pyrazoles/pharmacology; Pyrazoles/therapeutic use; Pyridones/pharmacology; Pyridones/therapeutic use; RNA, Small Interfering/pharmacology; Signal Transduction/drug effects; Signal Transduction/genetics

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Angiogenesis

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S. Garrido-Urbani et al., « Targeting vascular NADPH oxidase 1 blocks tumor angiogenesis through a PPARα mediated mechanism. », Serveur académique Lausannois, ID : 10.1371/journal.pone.0014665

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Abstract 0

Reactive oxygen species, ROS, are regulators of endothelial cell migration, proliferation and survival, events critically involved in angiogenesis. Different isoforms of ROS-generating NOX enzymes are expressed in the vasculature and provide distinct signaling cues through differential localization and activation. We show that mice deficient in NOX1, but not NOX2 or NOX4, have impaired angiogenesis. NOX1 expression and activity is increased in primary mouse and human endothelial cells upon angiogenic stimulation. NOX1 silencing decreases endothelial cell migration and tube-like structure formation, through the inhibition of PPARα, a regulator of NF-κB. Administration of a novel NOX-specific inhibitor reduced angiogenesis and tumor growth in vivo in a PPARα dependent manner. In conclusion, vascular NOX1 is a critical mediator of angiogenesis and an attractive target for anti-angiogenic therapies.

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