Elevated serum uric acid is associated with high circulating inflammatory cytokines in the population-based Colaus study.
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2011
- doi: 10.1371/journal.pone.0019901
- issn: 1932-6203
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Womyn Wimmin Woman Womon Human females People Man Humanity (Human beings) Human race Mankind Homo sapiens Humankind Humans Inflammatory process Older persons Older adults Seniors (Older people) Elderly people Old people Senior citizens Aging people Aged Women's workCiter ce document
Tanica Lyngdoh et al., « Elevated serum uric acid is associated with high circulating inflammatory cytokines in the population-based Colaus study. », Serveur académique Lausannois, ID : 10.1371/journal.pone.0019901
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BACKGROUND: The relation of serum uric acid (SUA) with systemic inflammation has been little explored in humans and results have been inconsistent. We analyzed the association between SUA and circulating levels of interleukin-6 (IL-6), interleukin-1beta (IL-1beta), tumor necrosis factor- alpha (TNF-alpha) and C-reactive protein (CRP). METHODS AND FINDINGS: This cross-sectional population-based study conducted in Lausanne, Switzerland, included 6085 participants aged 35 to 75 years. SUA was measured using uricase-PAP method. Plasma TNF-alpha, IL-1beta and IL-6 were measured by a multiplexed particle-based flow cytometric assay and hs-CRP by an immunometric assay. The median levels of SUA, IL-6, TNF-alpha, CRP and IL-1beta were 355 micromol/L, 1.46 pg/mL, 3.04 pg/mL, 1.2 mg/L and 0.34 pg/mL in men and 262 micromol/L, 1.21 pg/mL, 2.74 pg/mL, 1.3 mg/L and 0.45 pg/mL in women, respectively. SUA correlated positively with IL-6, TNF-alpha and CRP and negatively with IL-1beta (Spearman r: 0.04, 0.07, 0.20 and 0.05 in men, and 0.09, 0.13, 0.30 and 0.07 in women, respectively, P