NY-ESO-1-specific circulating CD4+ T cells in ovarian cancer patients are prevalently T(H)1 type cells undetectable in the CD25+ FOXP3+ Treg compartment.

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Date

2011

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Périmètre
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Serveur académique Lausannois

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Ce document est lié à :
info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0022845

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/pmid/21829534

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/eissn/1932-6203

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_D2DA924F4DF83

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Serveur Académique Lausannois

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Université de Lausanne et CHUV

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info:eu-repo/semantics/openAccess , Copying allowed only for non-profit organizations , https://serval.unil.ch/disclaimer

Mots-clés 0

Adenocarcinoma, Clear Cell/immunology; Adenocarcinoma, Clear Cell/metabolism; Adenocarcinoma, Mucinous/immunology; Adenocarcinoma, Mucinous/metabolism; Adult; Aged; Antigens, Neoplasm/immunology; Antigens, Neoplasm/metabolism; CD4-Positive T-Lymphocytes/immunology; CD4-Positive T-Lymphocytes/metabolism; Cystadenocarcinoma, Serous/immunology; Cystadenocarcinoma, Serous/metabolism; Female; Forkhead Transcription Factors/metabolism; Humans; Interleukin-10/metabolism; Interleukin-17/metabolism; Interleukin-2 Receptor alpha Subunit/metabolism; Lymphocyte Count; Major Histocompatibility Complex; Membrane Proteins/immunology; Membrane Proteins/metabolism; Middle Aged; Ovarian Neoplasms/immunology; Ovarian Neoplasms/metabolism; T-Lymphocytes, Regulatory/immunology; T-Lymphocytes, Regulatory/metabolism; Th1 Cells/immunology; Th1 Cells/metabolism

Sujets proches En

Thymus-dependent lymphocytes Thymus-derived cells T lymphocytes Thymus-dependent cells Retention (Psychology) Cancer survivors Survivors, Cancer Cancer patients Older persons Older adults Seniors (Older people) Elderly people Old people Senior citizens Aging people Aged

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N. Redjimi et al., « NY-ESO-1-specific circulating CD4+ T cells in ovarian cancer patients are prevalently T(H)1 type cells undetectable in the CD25+ FOXP3+ Treg compartment. », Serveur académique Lausannois, ID : 10.1371/journal.pone.0022845

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Spontaneous CD4(+) T-cell responses to the tumor-specific antigen NY-ESO-1 (ESO) are frequently found in patients with epithelial ovarian cancer (EOC). If these responses are of effector or/and Treg type, however, has remained unclear. Here, we have used functional approaches together with recently developed MHC class II/ESO tetramers to assess the frequency, phenotype and function of ESO-specific cells in circulating lymphocytes from EOC patients. We found that circulating ESO-specific CD4(+) T cells in EOC patients with spontaneous immune responses to the antigen are prevalently T(H)1 type cells secreting IFN-γ but no IL-17 or IL-10 and are not suppressive. We detected tetramer(+) cells ex vivo, at an average frequency of 1:25,000 memory cells, that is, significantly lower than in patients immunized with an ESO vaccine. ESO tetramer(+) cells were mostly effector memory cells at advanced stages of differentiation and were not detected in circulating CD25(+)FOXP3(+)Treg. Thus, spontaneous CD4(+) T-cell responses to ESO in cancer patients are prevalently of T(H)1 type and not Treg. Their relatively low frequency and advanced differentiation stage, however, may limit their efficacy, that may be boosted by immunogenic ESO vaccines.

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