Genome-wide association study to identify common variants associated with brachial circumference: a meta-analysis of 14 cohorts.

V. Boraska; A. Day-Williams; C.S. Franklin; K.S. Elliott; K. Panoutsopoulou; I. Tachmazidou; E. Albrecht; S. Bandinelli; L.J. Beilin; M. Bochud; G. Cadby; F. Ernst; D.M. Evans; C. Hayward; A.A. Hicks; J. Huffman; C. Huth; A.L. James; N. Klopp; I. Kolcic; Z. Kutalik; D.A. Lawlor; A.W. Musk; M. Pehlic; C.E. Pennell; J.R. Perry; A. Peters; O. Polasek; B.S. Pourcain; S.M. Ring; E. Salvi; S. Schipf; J.A. Staessen; A. Teumer; N. Timpson; V. Vitart; N.M. Warrington; H. Yaghootkar; T. Zemunik; L. Zgaga; P. An; V. Anttila; I.B. Borecki; J. Holmen; I. Ntalla; A. Palotie; K.H. Pietiläinen; J. Wedenoja; B.S. Winsvold; G.V. Dedoussis; J. Kaprio; M.A. Province; J.A. Zwart; M. Burnier; H. Campbell; D. Cusi; G. Davey Smith; T.M. Frayling; C. Gieger; L.J. Palmer; P.P. Pramstaller; I. Rudan; H. Völzke; H.E. Wichmann; A.F. Wright; E. Zeggini

Genome-wide association study to identify common variants associated with brachial circumference: a meta-analysis of 14 cohorts.

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Date

2012

Discipline

Anthropologie biologique

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Articles

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Anglais

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doi: 10.1371/journal.pone.0031369
issn: 1932-6203

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Serveur académique Lausannois

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info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0031369

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info:eu-repo/semantics/altIdentifier/pmid/22479309

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info:eu-repo/semantics/altIdentifier/eissn/1932-6203

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_8B56012693D24

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Serveur Académique Lausannois

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Université de Lausanne et CHUV

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info:eu-repo/semantics/openAccess , Copying allowed only for non-profit organizations , https://serval.unil.ch/disclaimer

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Group dynamics Association Groups, Social Human males

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V. Boraska et al., « Genome-wide association study to identify common variants associated with brachial circumference: a meta-analysis of 14 cohorts. », Serveur académique Lausannois, ID : 10.1371/journal.pone.0031369

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Brachial circumference (BC), also known as upper arm or mid arm circumference, can be used as an indicator of muscle mass and fat tissue, which are distributed differently in men and women. Analysis of anthropometric measures of peripheral fat distribution such as BC could help in understanding the complex pathophysiology behind overweight and obesity. The purpose of this study is to identify genetic variants associated with BC through a large-scale genome-wide association scan (GWAS) meta-analysis. We used fixed-effects meta-analysis to synthesise summary results across 14 GWAS discovery and 4 replication cohorts comprising overall 22,376 individuals (12,031 women and 10,345 men) of European ancestry. Individual analyses were carried out for men, women, and combined across sexes using linear regression and an additive genetic model: adjusted for age and adjusted for age and BMI. We prioritised signals for follow-up in two-stages. We did not detect any signals reaching genome-wide significance. The FTO rs9939609 SNP showed nominal evidence for association (p

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Genome-wide association study to identify common variants associated with brachial circumference: a meta-analysis of 14 cohorts.

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