Influence of MCHR2 and MCHR2-AS1 Genetic Polymorphisms on Body Mass Index in Psychiatric Patients and In Population-Based Subjects with Present or Past Atypical Depression.

A. Delacrétaz; M. Preisig; F. Vandenberghe; N. Saigi Morgui; L. Quteineh; E. Choong; M. Gholam-Rezaee; Z. Kutalik; P. Magistretti; J.M. Aubry; A. von Gunten; E. Castelao; P. Vollenweider; G. Waeber; P. Conus; C.B. Eap

Influence of MCHR2 and MCHR2-AS1 Genetic Polymorphisms on Body Mass Index in Psychiatric Patients and In Population-Based Subjects with Present or Past Atypical Depression.

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Date

2015

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Articles

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Anglais

Identifiants

doi: 10.1371/journal.pone.0139155
issn: 1932-6203

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Serveur académique Lausannois

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Ce document est lié à :
info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0139155

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/pmid/26461262

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/eissn/1932-6203

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_200412067B842

Collection

Serveur Académique Lausannois

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Université de Lausanne et CHUV

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info:eu-repo/semantics/openAccess , Copying allowed only for non-profit organizations , https://serval.unil.ch/disclaimer

Mots-clés 0

Adult; Body Mass Index; Depression/genetics; European Continental Ancestry Group/genetics; Genetic Association Studies; Genetic Predisposition to Disease; Haplotypes/genetics; Humans; Mental Disorders/genetics; Middle Aged; Polymorphism, Single Nucleotide/genetics; RNA, Long Noncoding/genetics; Receptors, G-Protein-Coupled/genetics; Receptors, Pituitary Hormone/genetics; Reproducibility of Results

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Group dynamics Association Groups, Social

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A. Delacrétaz et al., « Influence of MCHR2 and MCHR2-AS1 Genetic Polymorphisms on Body Mass Index in Psychiatric Patients and In Population-Based Subjects with Present or Past Atypical Depression. », Serveur académique Lausannois, ID : 10.1371/journal.pone.0139155

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Obesity development during psychotropic treatments represents a major health issue in psychiatry. Melanin-concentrating hormone receptor 2 (MCHR2) is a central receptor involved in energy homeostasis. MCHR2 shares its promoter region with MCHR2-AS1, a long antisense non-coding RNA. The aim of this study was to determine whether tagging single nucleotide polymorphisms (tSNPs) of MCHR2 and MCHR2-AS1 are associated with the body mass index (BMI) in the psychiatric and in the general population. The influence of MCHR2 and MCHR2-AS1 tSNPs on BMI was firstly investigated in a discovery psychiatric sample (n1 = 474). Positive results were tested for replication in two other psychiatric samples (n2 = 164, n3 = 178) and in two population-based samples (CoLaus, n4 = 5409; GIANT, n5 = 113809). In the discovery sample, TT carriers of rs7754794C>T had 1.08 kg/m2 (p = 0.04) lower BMI as compared to C-allele carriers. This observation was replicated in an independent psychiatric sample (-2.18 kg/m2; p = 0.009). The association of rs7754794C>T and BMI seemed stronger in subjects younger than 45 years (median of age). In the population-based sample, a moderate association was observed (-0.17 kg/m2; p = 0.02) among younger individuals (

Influence of MCHR2 and MCHR2-AS1 Genetic Polymorphisms on Body Mass Index in Psychiatric Patients and In Population-Based Subjects with Present or Past Atypical Depression.

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