Predictors and Implications of Early Clinical Stability in Patients Hospitalized for Moderately Severe Community-Acquired Pneumonia.

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Date

2016

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Périmètre
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Serveur académique Lausannois

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Ce document est lié à :
info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0157350

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/pmid/27305046

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info:eu-repo/semantics/altIdentifier/eissn/1932-6203

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_D0B195B53E949

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Serveur Académique Lausannois

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Université de Lausanne et CHUV

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info:eu-repo/semantics/openAccess , Copying allowed only for non-profit organizations , https://serval.unil.ch/disclaimer

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Adult; Age Factors; Aged; Community-Acquired Infections/drug therapy; Community-Acquired Infections/pathology; Female; Hospitalization/statistics & numerical data; Humans; Length of Stay/statistics & numerical data; Male; Middle Aged; Multicenter Studies as Topic; Multivariate Analysis; Outcome Assessment (Health Care)/methods; Outcome Assessment (Health Care)/statistics & numerical data; Pneumonia/drug therapy; Pneumonia/pathology; Prognosis; Randomized Controlled Trials as Topic; Severity of Illness Index; Time Factors; Young Adult

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N. Garin et al., « Predictors and Implications of Early Clinical Stability in Patients Hospitalized for Moderately Severe Community-Acquired Pneumonia. », Serveur académique Lausannois, ID : 10.1371/journal.pone.0157350

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Assessment of early response to treatment is crucial for the management of community-acquired pneumonia (CAP). To describe the predictors and the outcomes of early clinical stability. We did a secondary analysis of a multicentre randomized controlled trial on CAP treatment in which 580 patients hospitalized for moderately severe CAP were included. The association between demographic, clinical and biological variables available at inclusion and early clinical stability (stabilization of vital signs within 72 hours with predetermined cut-offs) was assessed by multivariate logistic regression. The association between early clinical stability and mortality, severe adverse events, and length of stay was also tested. Younger age (OR 0.98, 95% CI 0.96-0.99), lower platelet count (OR per 10 G/L increment 0.96, 95% CI 0.94-0.98), lower respiratory rate (OR 0.94, 95% CI 0.90-0.97), absence of hypoxemia (OR 0.58, 95% CI 0.40-0.85), lower numbers of co-morbid conditions (OR 0.82, 95% CI 0.69-0.98) and signs or symptoms (OR 0.78, 95% CI 0.68-0.90) were significantly associated with early clinical stability. Patients with early clinical stability had lower 90-days mortality (3.4% vs. 11.9%, p

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