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2017
- doi: 10.1371/journal.pone.0175776
- issn: 1932-6203
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Populations, Human Human populations Population growth Human population Biologic markers Biological markers Biomarkers Markers, Biochemical Demography DemographicsCiter ce document
J. Mwinyi et al., « Plasma 1-deoxysphingolipids are early predictors of incident type 2 diabetes mellitus. », Serveur académique Lausannois, ID : 10.1371/journal.pone.0175776
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1-Deoxysphingolipids (1-deoxySLs) are atypical sphingolipids, which are formed in a side reaction during sphingolipid de-novo synthesis. Recently, we demonstrated that 1-deoxySLs are biomarkers for the prediction of T2DM in obese, non-diabetic patients. Here we investigated the relevance of 1-deoxySLs as long-term predictive biomarkers for the incidence of T2DM in an asymptomatic population. Here, we analyzed the plasma sphingoid base profile in a nested group of non-diabetic individuals (N = 605) selected from a population-based study including 5 year follow-up data (CoLaus study). 1-DeoxySLs at baseline were significantly elevated in individuals who developed T2DM during the follow-up (p