Rapid high resolution T1 mapping as a marker of brain development: Normative ranges in key regions of interest.
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2018
- doi: 10.1371/journal.pone.0198250
- issn: 1932-6203
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info:eu-repo/semantics/altIdentifier/pmid/29902203
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info:eu-repo/semantics/altIdentifier/eissn/1932-6203
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info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_722D3FA1CEE89
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S. Eminian et al., « Rapid high resolution T1 mapping as a marker of brain development: Normative ranges in key regions of interest. », Serveur académique Lausannois, ID : 10.1371/journal.pone.0198250
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Résumé
We studied in a clinical setting the age dependent T1 relaxation time as a marker of normal late brain maturation and compared it to conventional techniques, namely the apparent diffusion coefficient (ADC). Forty-two healthy subjects ranging from ages 1 year to 20 years were included in our study. T1 brain maps in which the intensity of each pixel corresponded to T1 relaxation times were generated based on MR imaging data acquired using a MP2RAGE sequence. During the same session, diffusion tensor imaging data was collected. T1 relaxation times and ADC in white matter and grey matter were measured in seven clinically relevant regions of interest and were correlated to subjects' age. In the basal ganglia, there was a small, yet significant, decrease in T1 relaxation time (-0.45 ≤R≤-0.59, p