Predictors of residual antimalarial drugs in the blood in community surveys in Tanzania.

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Auteurs
Date

2018

Type de document
Périmètre
Langue
Identifiants
Source

Serveur académique Lausannois

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Ce document est lié à :
info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0202745

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/pmid/30192770

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/eissn/1932-6203

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_05548CB69DD58

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Serveur Académique Lausannois

Organisation

Université de Lausanne et CHUV

Licences

info:eu-repo/semantics/openAccess , CC BY 4.0 , https://creativecommons.org/licenses/by/4.0/

Mots-clés 0

Adolescent; Adult; Aged; Aged, 80 and over; Antimalarials/blood; Antimalarials/therapeutic use; Child; Child, Preschool; Cross-Sectional Studies; Drug Residues/analysis; Female; Humans; Infant; Infant, Newborn; Malaria/blood; Malaria/drug therapy; Male; Middle Aged; Surveys and Questionnaires; Tanzania; Young Adult

Sujets proches En

Therapy Factors Agents, Manufacturers' Manufacturers' representatives Ague Chills and fever Intermittent fever Malarial fever Hyperthermia Pyrexia Medications Medicaments Prescription drugs Medicines (Drugs) Pharmaceuticals Medicine (Drugs) Factors Older persons Older adults Seniors (Older people) Elderly people Old people Senior citizens Aging people Aged

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J. Gallay et al., « Predictors of residual antimalarial drugs in the blood in community surveys in Tanzania. », Serveur académique Lausannois, ID : 10.1371/journal.pone.0202745

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Understanding pattern of antimalarials use at large scale helps ensuring appropriate use of treatments and preventing the spread of resistant parasites. We estimated the proportion of individuals in community surveys with residual antimalarials in their blood and identified the factors associated with the presence of the most commonly detected drugs, lumefantrine and/or desbutyl-lumefantrine (LF/DLF) or sulfadoxine-pyrimethamine (SP). A cross-sectional survey was conducted in 2015 in three regions of Tanzania with different levels of malaria endemicity. Interviews were conducted and blood samples collected through household surveys for further antimalarial measurements using liquid chromatography coupled to tandem mass spectrometry. In addition, diagnosis and treatment availability was investigated through outlet surveys. Multilevel mixed effects logistic regression models were used to estimate odds ratios for having LF/DLF or SP in the blood. Amongst 6391 participants, 12.4% (792/6391) had LF/DLF and 8.0% (510/6391) SP in the blood. Factors associated with higher odds of detecting LF/DLF in the blood included fever in the previous two weeks (OR = 2.6, p

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