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12 mars 2019
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info:eu-repo/semantics/altIdentifier/doi/10.15203/CISS_2019.002
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info:eu-repo/semantics/altIdentifier/eissn/2414-6641
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info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_C6C4BEB2A8955
info:eu-repo/semantics/openAccess , CC BY 4.0 , https://creativecommons.org/licenses/by/4.0/
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B. Kayser et al., « Iloprost improves running performance at 5,000 m in Han but not in Tibetans », Serveur académique Lausannois, ID : 10.15203/CISS_2019.002
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Background: Tibetans lose less aerobic exercise capacity in hypoxia compared to lowland Han. We tested if inhalation of iloprost (to counter hypoxic pulmonary vasoconstriction) and furosemide (to decrease afferent vagal traffic from pulmonary receptors) improve performance in hypoxia in Han compared to Tibetans. Methods: 8 Tibetans and 8 Han, living at 2,260 m, did incremental uphill treadmill running to exhaustion at ambient pressure on day 1, followed by three runs at 5,000 m (hypobaric chamber) after inhalation of iloprost (ILO), furosemide (FUR) or placebo (PLA), on different days in a counter-balanced order. Results: In Han the performance decrement from 2,260 m to 5,000 m was greater than in Tibetans (p