Beyond inflammasomes: emerging function of gasdermins during apoptosis and NETosis.

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15 janvier 2020

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Serveur académique Lausannois

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Ce document est lié à :
info:eu-repo/semantics/altIdentifier/doi/10.15252/embj.2019103397

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/pmid/31793683

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/eissn/1460-2075

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_82D60FA890A57

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Serveur Académique Lausannois

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Université de Lausanne et CHUV

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info:eu-repo/semantics/openAccess , Copying allowed only for non-profit organizations , https://serval.unil.ch/disclaimer

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Apoptosis; Humans; Inflammasomes/metabolism; Intracellular Signaling Peptides and Proteins/immunology; Intracellular Signaling Peptides and Proteins/metabolism; Necrosis; Neoplasms/metabolism; Neoplasms/pathology; Neutrophils/metabolism; Neutrophils/pathology; Phosphate-Binding Proteins/immunology; Phosphate-Binding Proteins/metabolism; Pyroptosis; NETosis; apoptosis; gasdermin; inflammasome; pyroptosis

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Cell degeneration

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K.W. Chen et al., « Beyond inflammasomes: emerging function of gasdermins during apoptosis and NETosis. », Serveur académique Lausannois, ID : 10.15252/embj.2019103397

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Programmed cell death is a key mechanism involved in several biological processes ranging from development and homeostasis to immunity, where it promotes the removal of stressed, damaged, malignant or infected cells. Abnormalities in the pathways leading to initiation of cell death or removal of dead cells are consequently associated with a range of human diseases including infections, autoinflammatory disease, neurodegenerative disease and cancer. Apoptosis, pyroptosis and NETosis are three well-studied modes of cell death that were traditionally believed to be independent of one another, but emerging evidence indicates that there is extensive cross-talk between them, and that all three pathways can converge onto the activation of the same cell death effector-the pore-forming protein Gasdermin D (GSDMD). In this review, we highlight recent advances in gasdermin research, with a particular focus on the role of gasdermins in pyroptosis, NETosis and apoptosis, as well as cell type-specific consequences of gasdermin activation. In addition, we discuss controversies surrounding a related gasdermin family protein, Gasdermin E (GSDME), in mediating pyroptosis and secondary necrosis following apoptosis, chemotherapy and inflammasome activation.

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