Fiche du document
2012
- doi: 10.1681/ASN.2011080842
- issn: 1046-6673
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/doi/10.1681/ASN.2011080842
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/pmid/22440902
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/eissn/1533-3450
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_4E9C79612EC02
info:eu-repo/semantics/openAccess , Copying allowed only for non-profit organizations , https://serval.unil.ch/disclaimer
Sujets proches
Mouse House mice Mus musculus House mouseCiter ce document
S. Nikolaeva et al., « The circadian clock modulates renal sodium handling. », Serveur académique Lausannois, ID : 10.1681/ASN.2011080842
Métriques
Partage / Export
Résumé
The circadian clock contributes to the control of BP, but the underlying mechanisms remain unclear. We analyzed circadian rhythms in kidneys of wild-type mice and mice lacking the circadian transcriptional activator clock gene. Mice deficient in clock exhibited dramatic changes in the circadian rhythm of renal sodium excretion. In parallel, these mice lost the normal circadian rhythm of plasma aldosterone levels. Analysis of renal circadian transcriptomes demonstrated changes in multiple mechanisms involved in maintaining sodium balance. Pathway analysis revealed the strongest effect on the enzymatic system involved in the formation of 20-HETE, a powerful regulator of renal sodium excretion, renal vascular tone, and BP. This correlated with a significant decrease in the renal and urinary content of 20-HETE in clock-deficient mice. In summary, this study demonstrates that the circadian clock modulates renal function and identifies the 20-HETE synthesis pathway as one of its principal renal targets. It also suggests that the circadian clock affects BP, at least in part, by exerting dynamic control over renal sodium handling.