A multi-omics approach to investigate the inflammatory response to life course socioeconomic position.
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- doi: 10.2217/epi-2019-0261
- issn: 1750-192X
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info:eu-repo/semantics/altIdentifier/pmid/32875816
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info:eu-repo/semantics/altIdentifier/eissn/1750-192X
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info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_C6E5F1EF03CD3
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Life--PhilosophyCiter ce document
R. Castagné et al., « A multi-omics approach to investigate the inflammatory response to life course socioeconomic position. », Serveur académique Lausannois, ID : 10.2217/epi-2019-0261
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Aim: Inflammation represents a potential pathway through which socioeconomic position (SEP) is biologically embedded. Materials & methods: We analyzed inflammatory biomarkers in response to life course SEP by integrating multi-omics DNA-methylation, gene expression and protein level in 178 European Prospective Investigation into Cancer and Nutrition-Italy participants. Results & conclusion: We identified 61 potential cis acting CpG loci whose methylation levels were associated with gene expression at a Bonferroni correction. We examined the relationships between life course SEP and these 61 cis-acting regulatory methylation sites individually and jointly using several scores. Less-advantaged SEP participants exhibit, later in life, a lower inflammatory methylome score, suggesting an overall increased expression of the corresponding inflammatory genes or proteins, supporting the hypothesis that SEP impacts adult physiology through inflammation.
