Re-education of macrophages as a therapeutic strategy in cancer.

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Serveur académique Lausannois

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Ce document est lié à :
info:eu-repo/semantics/altIdentifier/doi/10.2217/imt-2018-0156

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/pmid/31088236

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info:eu-repo/semantics/altIdentifier/eissn/1750-7448

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_7E2B9DDA760A2

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Serveur Académique Lausannois

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Université de Lausanne et CHUV

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info:eu-repo/semantics/openAccess , CC BY-NC-ND 4.0 , https://creativecommons.org/licenses/by-nc-nd/4.0/

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Animals; Humans; Immunotherapy; Macrophages/immunology; Macrophages/pathology; Neoplasms/immunology; Neoplasms/pathology; Neoplasms/therapy; Tumor Microenvironment/immunology; anticancer treatment; cancer immunotherapy; macrophages; tumor microenvironment; tumor-associated macrophages

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Mononuclear phagocytes Histiocytes

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J. Kowal et al., « Re-education of macrophages as a therapeutic strategy in cancer. », Serveur académique Lausannois, ID : 10.2217/imt-2018-0156

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Tumor-associated macrophages (TAMs) can be educated within the tumor microenvironment to promote cancer development and progression. While TAM-targeted agents have largely focused on macrophage depletion as an anticancer strategy, it is becoming increasingly evident that TAM re-education may represent a more effective approach. In this perspective, we discuss different means to achieve TAM re-education, and review the beneficial effects of these strategies, particularly when combined with immune checkpoint inhibitors.

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