Plasma Proteomic Profiles of Cerebrospinal Fluid-Defined Alzheimer's Disease Pathology in Older Adults.

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Date

2017

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Périmètre
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Serveur académique Lausannois

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Ce document est lié à :
info:eu-repo/semantics/altIdentifier/doi/10.3233/JAD-170426

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/pmid/29125490

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/eissn/1875-8908

Ce document est lié à :
info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_1A9D88852EEA4

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Serveur Académique Lausannois

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Université de Lausanne et CHUV

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info:eu-repo/semantics/openAccess , Copying allowed only for non-profit organizations , https://serval.unil.ch/disclaimer

Mots-clés 0

Aged; Alzheimer Disease/blood; Alzheimer Disease/cerebrospinal fluid; Alzheimer Disease/genetics; Amyloid beta-Peptides/cerebrospinal fluid; Apolipoprotein E4/genetics; Area Under Curve; Biomarkers/blood; Biomarkers/cerebrospinal fluid; Cognitive Dysfunction/blood; Cognitive Dysfunction/cerebrospinal fluid; Cognitive Dysfunction/genetics; Cross-Sectional Studies; Enzyme-Linked Immunosorbent Assay; Female; Humans; Male; Mass Spectrometry; Peptide Fragments/cerebrospinal fluid; Phosphorylation; Proteome; Proteomics; ROC Curve; tau Proteins/cerebrospinal fluid; Alzheimer’s disease; amyloid-β; amyloidosis; biomarker; dementia; protein; tau

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Disease (Pathology) Plasma proteins Serum proteins

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L. Dayon et al., « Plasma Proteomic Profiles of Cerebrospinal Fluid-Defined Alzheimer's Disease Pathology in Older Adults. », Serveur académique Lausannois, ID : 10.3233/JAD-170426

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Cerebrospinal fluid (CSF) biomarkers of the beta-amyloid and microtubule associated protein tau metabolism have proven the capacity to improve classification of subjects developing Alzheimer's disease (AD). The blood plasma proteome was characterized to further elaborate upon the mechanisms involved and identify proteins that may improve classification of older adults developing an AD dementia. Identify and describe plasma protein expressions that best classify subjects with CSF-defined presence of AD pathology and cerebral amyloidosis. We performed a cross-sectional analysis of samples collected from community-dwelling elderly with (n = 72) or without (n = 48) cognitive impairment. CSF Aβ1-42, tau, and phosphorylated tau (P-tau181) were measured using ELISA, and mass spectrometry quantified the plasma proteomes. Presence of AD pathology was defined as CSF P-tau181/Aβ1-42 > 0.0779, and presence of amyloidosis was defined as CSF Aβ1-42 

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