Genetic variation near CXCL12 is associated with susceptibility to HIV-related non-Hodgkin lymphoma.
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1 août 2021
- doi: 10.3324/haematol.2020.247023
- issn: 0390-6078
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info:eu-repo/semantics/altIdentifier/pmid/32675224
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Lymphoma Non-Hodgkin's lymphoma Germinoblastomas Sarcoma, Germinoblastic Sarcoma, Immunoblastic Reticulolymphosarcomas ImmunoblastomasCiter ce document
C.W. Thorball et al., « Genetic variation near CXCL12 is associated with susceptibility to HIV-related non-Hodgkin lymphoma. », Serveur académique Lausannois, ID : 10.3324/haematol.2020.247023
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Human immunodeficiency virus (HIV) infection is associated with an increased risk of non-Hodgkin lymphoma (NHL). Even in the era of suppressive antiretroviral treatment, HIV-infected individuals remain at higher risk of developing NHL compared to the general population. To identify potential genetic risk loci, we performed case-control genome-wide association studies and a meta-analysis across three cohorts of HIV+ patients of European ancestry, including a total of 278 cases and 1924 matched controls. We observed a significant association with NHL susceptibility in the C-X-C motif chemokine ligand 12 (CXCL12) region on chromosome 10. A fine mapping analysis identified rs7919208 as the most likely causal variant (P = 4.77e-11), with the G>A polymorphism creating a new transcription factor binding site for BATF and JUND. These results suggest a modulatory role of CXCL12 regulation in the increased susceptibility to NHL observed in the HIV-infected population.