Impact of 18F-FDG PET/CT in Staging Patients With Small Cell Lung Cancer: A Systematic Review and Meta-Analysis.
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2019
- doi: 10.3389/fmed.2019.00336
- issn: 2296-858X
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info:eu-repo/semantics/altIdentifier/doi/10.3389/fmed.2019.00336
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/pmid/32118000
Ce document est lié à :
info:eu-repo/semantics/altIdentifier/pissn/2296-858X
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info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_63100DA323FC8
info:eu-repo/semantics/openAccess , CC BY 4.0 , https://creativecommons.org/licenses/by/4.0/
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lung cancer; molecular imaging; positron emission tomography/CT; small cell lung cancer; stagingSujets proches
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F. Martucci et al., « Impact of 18F-FDG PET/CT in Staging Patients With Small Cell Lung Cancer: A Systematic Review and Meta-Analysis. », Serveur académique Lausannois, ID : 10.3389/fmed.2019.00336
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Background: Molecular imaging methods are currently used in the management of patients with lung cancer. Compared to non-small cell lung cancer, less data are available about the impact of molecular imaging using fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography ( 18 F-FDG PET/CT) in staging patients with small cell lung cancer (SCLC). Performing a systematic review and meta-analysis, we aimed to provide quantitative data about the impact of 18 F-FDG PET/CT in staging SCLC. Methods: A comprehensive literature search of studies on the use of 18 F-FDG PET/CT in patients with SCLC was performed. Three different databases were screened (PubMed/MEDLINE, EMBASE, and Cochrane library databases) until June 2019. Only articles describing the impact of 18 F-FDG PET/CT in staging patients with SCLC were selected. A pooled analysis evaluating the change of binary SCLC staging (limited-stage vs. extensive-stage disease) using 18 F-FDG PET/CT was carried out. Results: Nine articles including 721 patients with SCLC were included in the systematic review. Compared to conventional staging, a superior diagnostic accuracy of 18 F-FDG PET/CT was found. A change of binary SCLC staging using 18 F-FDG PET/CT was demonstrated in 15% (95% confidence interval, 9-21%) of patients with SCLC. Currently, it is not clearly demonstrated that the use of 18 F-FDG PET/CT for staging may improve the survival outcome of patients with SCLC. Conclusions: 18 F-FDG PET/CT is a useful molecular imaging method for staging patients with SCLC because it can change the management in a significant number of patients. More large prospective studies and cost-effectiveness analyses on the impact of 18 F-FDG PET/CT in staging patients with SCLC are needed.